The Western New York Image and Signal Processing Workshop ((https://ewh.ieee.org/r1/rochester/sp/WNYISPW2021.html)) is a venue for promoting image and signal processing research in our area and for facilitating interaction between academic researchers, industry researchers, and students. The workshop comprises both oral and poster presentations. The workshop, building off of 22 successful years of the Western New York Image Processing Workshop (WNYIPW), is brought to you by (https://www.orolia.com/), with financial support from (https://www.src.com/) and (https://www.mathworks.com/), sponsored by the (https://ewh.ieee.org/r1/rochester/sp/index.html) of the IEEE Signal Processing Society and with technical cooperation from the Rochester chapter of the Society for Imaging Science and Technology. The workshop will be held in a hybrid format on Friday, October 22, 2021 from 8:30am to 5:30pm. In-Person Location: RIT Inn and Conference Center 5257 W Henrietta Rd Henrietta, NY 14467 Paper Submission Opens: August 12th, 2021 Final Extension: Full Paper Submission Closes: September 24th, 2021 Final Extension: Abstract Only Submission Closes: September 27th, 2021 Virtual: https://events.vtools.ieee.org/m/268865